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Since 2003 (*MS related)
*Naasani,
I, Oh-hashi, F, Oh-hara, T, Feng, WY, Johnston,
J, Chan ,K, and Tsuruo,T.
Blocking Telomerase by
Dietary Polyphenols Is a Major Mechanism for Limiting the Growth of
Human Cancer Cells in vitro and in vivo. Cancer Res. 63:
824-830, 2003.
*Xiao,
JJ, Byrd, J, Marcucci, G,
Grever, M, and Chan, KK.* Identification of Thiols and Glutathione
Conjugates of Depsipeptide FK228 (FR901228), a Novel Histone Protein
Deacetylase Inhibitor, in the Blood. Rapid Comm Mass Spectrometry 17(8):757-766,
2003.
Klisovic,
MI, Maghraby, EA, Parthun, R, Guimond, M, Sklenar, AR, Whitman, SP,
Chan, KK, Murphy, T, Anon, J, Archer, KJ, Rush, LJ, Plass, C, Grever,
MR, Byrd, JC, and Marcucci, G.* Depsipeptide (FR 901228) Promotes
Histone Acetylation, Gene Transcription, Apoptosis, and its Activity is
Enhanced by DNA Methyltransferase Inhibitors in AML1/ETO-positive
leukemic cells. Leukemia 17:350-358, 2003.
Gao, H,
Yamasaki, EF, Chan, KK, Shen, LL, and Snapka, RM.* DNA Sequence
Specificity for Topoisomerase II Poisoning by the Quinoxaline
Anticancer Drugs XK469 and CQS. Mol Pharmacol 63(6): 1382-1388,
2003.
Castelao, JE,
Yuan, J-M, Gago-Dominguez, M, Skipper, PL, Tannenbaum, SR, Chan, KK,
Watson, MA, Bell, DA, Coetzee, GA, Ross, RK, and Yu, MC.
Carotenoids/vitamin C and Smoking-related Bladder Cancer. Int J Cancer 110:
417-423, 2004.
*Berg, SL,
Stone, J, Xiao, JJ, Chan, KK, Nuchtern, J, Dauser, R, McGuffey, L, and
Blaney SM. Plasma and Cerebrospinal Fluid Pharmacokinetics of
Depsipeptide (FR901228) in Nonhuman Primates. Cancer Pharmacol
Pharmacol 54(1):85-88, 2004.
*Hua,
Y, Fan-Havard,
P, and Chan, KK.* A
Subnanogram On-line Column-switch LC/MS/MS Quantification Method for
Nelfinavir and Methoxy-phenol Metabolite M1 in Rat Plasma. J Chromatog
B 809(1): 1-7, 2004.
Marcucci, G,
Stock, W, Dai, G, Klisovic, MI, Maharry, K, Shen, T, Liu, S, Larson,
RA, Caliguiri, MA, Bloomfield, CD, Chan, KK, Grever, MR, Byrd, JC. G
3139, a BCL-2 antisense oligonucleotide, in AML. Ann Hematol. 83:S93-4,
2004.
Roychowdhury, S,
Baiocchi, R, Vourganti, S, Bhatt, D, Blaser, BW, Freud, AG, Chou,
J,Chen, Chang-Shi, Xiao, JJ, Parthun, M, Chan, KK, Eisenbeis, CF,
Ferketich, AK, Grever, MR, Chen, Ching-Shih, and Caligiuri, MA.
Selective Efficacy of Depsipeptide in a Xenograft Model of Epstein-Barr
Virus-Positive Lymphoproliferative Disorder. J Natl Cancer Inst. 96(19):
4471457, 2004.
*Liu, Z, Floss,
HG, Cassady, JM, Xiao, J, and Chan, KK.
An API LC/MS/MS Quantitation Method for
Ansamitocin P-3 (AP3) and its Preclinical Pharmacokinetics. J Pharm
Biomed Anal 36(4): 815-821, 2004.
*Liu,
Z, Floss, HG, Cassady, JM, and Chan, KK. Metabolism Studies of the Anti-tumor Agent Maytansine and Its Analog
Ansamitocin P-3 Using Liquid Chromatography/Tandem Mass Spectrometry. J
Mass Spectrom. 40(3): 389-399, 2005.
John
M. Cassady, Kenneth K. Chan, Heinz G. Floss, and Eckhard Leistner.
Recent Developments in the maytansinoid antitumor agents. In Chem Pharm
Bull, 52(1)1-26, 2004. BOOK
CHAPTER
*Xiao, JJ,
Foraker, AB, Swaan, PW, Liu, S, Huang, Y, Dai, Z, Chen, J, Sadee, W,
Byrd,J, Marcucci, G, and Chan KK. Efflux of Depsipeptide FK228
(FR901228, NSC-630176) is Mediated by both P-glycoprotein and MRP1. J
Pharmacol Exp Thera. 313(1): 268-276, 2005.
*Byrd,
JC, Marcucci, G, Parthun, MR,
Xiao, JJ, Klisovic, RB, Moran, M, Lin, TS, Liu, S, Wickham, J, Davis,
ME, Lucas, DM, Fischer, B, Shank, R, Binkley, B, Wright, J, Chan, KK,
and Grever, MR. A phase 1 and
pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia
and acute myeloid leukemia. Blood 105(3): 959-957, 2005.
Otterson,
GA, Lavelle, J, Villalona-Calero, MA,
Shah, M, Wei, X, Chan, KK, Fischer, B, Grever, M. A Phase I Clinical
and Pharmacokinetic Study of Fenretinide Combined with Paclitaxel and
Cisplatin for Refractory Solid Tumors. Invest. New Drugs, 23(6):
555-562, 2005.
Xiao,
JJ, Huang, Y, Dai, Z, Liu, S, Chen, J, Covey, JM, Wright, JM, Byrd, J,
Marcucci, G, Sadée, W and Chan,
KK. Chemo-resistance to depsipeptide FK228 is mediated by reversible
MDR1 induction in human cancer cell lines. J Pharmacol Exp Thera. 314(1): 467-475, 2005.
Huang,
Y, Blower, PE, Yang, C, Barbacioru, C, Dai, Z, Zhang, Y, Xiao, JJ,
Chan, KK, and Sadée, W.
Correlating gene expression with chemical scaffolds of cytotoxic
agents: ellipticines as substrates and inhibitors of MDR1. The
Pharmacogenomics Journal 5:112-125, 2005.
Dai,
G, Chan, KK, Liu, S, Hoyt, D, Whitman, S, Klisovic, M, Shen, TS,
Caliguri, MA, Byrd, J, Grever, M, and Marcucci, G. Cellular uptake and
intracellular levels of the Bcl-2 antisense G3139 in cultured cells,
and treated patients with acute myeloid leukemia. Clin Cancer Res, 11(8):2998-3008,
2005.
Marcucci,
G, Stock, W, Dai, G, Klisovic, RB, Liu, S, Klisovic, MI, Blum, W,
Kefauver, C, Sher, DA, Green, M,
Moran, M, Maharry, K, Novick, S, Bloomfield, CD, Zwiebel, JA, Larson,
RA, Grever, MR, Chan, KK, and Byrd, JC.
Phase I Study of Oblimersen Sodium, an Antisense to Bcl-2, in
Untreated Older Patients with Acute Myeloid Leukemia: Pharmacokinetics,
Pharmacodynamics and Clinical Activity.
J Clin Oncology, 23(15): 3404-3411, 2005.
*Dai,
G, Wei, X, Liu, Z, Liu, S, Marcucci, G, Chan, KK. Characterization and
quantification of Bcl-2 antisense G3139 and metabolites in plasma and
urine by ion-pair reversed phase HPLC coupled with electrospray
ion-trap mass spectrometry. J
Chromatogr B 825(2): 201-213, 2005. (Invited manuscript)
*Liu, Z, Chan,
KK, and Wang, JJ. Tandem mass spectrometric analysis of
cyclophosphamide, ifosfamide and their metabolites. Rapid Comm Mass Spectrom,
19(18): 2581-2590, 2005.
Bekaii-Saab,
T, Mortazavi, A, Hicks, LG, Zalpuski, M, Pelley, R. J, Chan, KK,
and Kraut, EH. A phase II study
of chloroquinoxaline sulfonamide (CQS) in patients with metastatic
colorectal carcinoma (MCRC). Invest New Drugs 24(4):343-346,
2006.
Zhang,
Y, Hua, Y, Benbrook, D, Covey, JM, Dai, G, Liu, Z, and Chan, KK.
High Performance Liquid Chromatographic Analysis and Preclinical
Pharmacokinetics of the Heteroarotinoid Antitumor Agent, SHetA2.
Cancer Chemother Pharmacol. 58(5):561-569,
2006.
*Liu,
Z, Marcucci, G, Byrd, JC, Grever, M, Xiao, J, and Chan, KK.
Characterization of Decomposition Products and Preclinical and Low Dose
Clinical Pharmacokinetics of Decitabine (5-aza-2’-deoxycytidine)
by a New Liquid Chromatography Tandem Mass Spectrometry Quantification
Method. Rapid Comm Mass Spectrom, 20(7):1117-1126, 2006.
Wei,
X, Dai, G, Marcucci, G, Liu, Z, Hoyt, D, Blum, W, and Chan, KK. A
Specific Picomolar Hybridization-based ELISA Assay for the
Determination of Phosphorothioate Oligonucleotides in Plasma and
Cellular Matrices. Pharm Res, 23(6):1251-1264, 2006.
O’Connor, OA, Smith, EA, Toner, LE,
Teruya-Feldstein, J, Frankel, S, Rolfe, M, Wei, X, Liu, S, Marcucci, G,
Chan, KK, and Chanan-Khan, A. The Combination of the Proteasome
Inhibitor Bortezomib and the Bcl-2 Antisense Molecule Oblimersen
Sensitizes Human B-Cell Lymphomas to Cyclophosphamide. Clin Cancer Res,
12(9): 2902-2911, 2006.
Shah, MH, Binkley, P, Chan, KK, Xiao, J, Arbogast, D,
Collamore, M, Farra, Y, Young, D, Wright, J, and Grever, M.
Cardiotoxicity of Histone Deacetylase Inhibitor Depsipeptide in
Patients with Metastic Neuroendocrine Tumors. Clin Cancer Res, 12(13):
3997-4003, 2006.
Stram,
DO, Yuan, J-M, Chan, KK, Gao, Y-T, Ross, RK, Yu, MC. Beta-cryptoxanthin and Lung Cancer in
Shanghai, China -an Examination of
Potential Confounding with Cigarette Smoking Using Urinary Cotinine as
a Biomarker of True Tobacco Exposure.
Nutrition and Cancer, 57(2): 123-129, 2006.
*Perera,
M, Yin, D, Wu, D, Chan, KK, Miller, D, and Dalton, JT. In Vivo Metabolism and
Final Disposition of a Novel Nonsteroidal Androgen in Rats and
Dogs. Drug Metabolism and
Disposition, 34(10): 1713-1721, 2006.
Fang,
L, Zhang, G, Zhang, Li, C, Zheng, X, Zhu, L, Xiao, JJ, Szakacs, G,
Nadas, J, Chan, KK, Wang PG, and Sun, D. Discovery of a Daunorubicin Analogue
that Exhibits Potent Antitumor Activity and Overcomes P-gp-mediated drug
resistance. J Med Chem 49(3): 932-941, 2006.
Fang,
L, Battisti, RF, Cheng, H, Reigan, P, Xin, Y, Shen, J, Ross, D, Chan,
KK, Martin, EW, Wang, PG, and Sun, D.
Enzyme Specific Activation of Benzoquinone Ansamycin Prodrugs
Using HuCC49∆CH2-β-Galactosidase Conjugates. J Med Chem 49(21): 6290- 6297, 2006.
Fang,
L, Nicholas, HG, Holford, MB, Hinkle, G, Cao, X, Xiao, JJ, Bloomston,
MP, Gibbs, S, Al Saif, OH, Dalton, JT, Chan, KK, Schlom, J, Martin, E,
and Sun, D. Population Pharmacokinetics of Humanized Monoclonal
Antibody HuCC49∆CH2 and Murine Antibody CC49 in Colorectal Cancer
Patients. J Clin Pharmacol, 47(2): 227-237, 2007.
*Wei,
X, Dai, G, Liu, Z, Cheng, H, Xie, Z, Marcucci, G, Chan, KK. Metabolism of GTI-2040, a
Phosphorothioate Oligonucleotide Antisense, Using Ion-pair Reversed
Phase High Performance Liquid Chromatography (HPLC) Coupled with
Electrospray Ion-trap Mass Spectrometry. AAPSJ, 8(4) article 84, 2006. (Invited
manuscript)
*Cheng, H, Liu, Z, Blum, W,
Byrd, J, Klisovic, R, Grever, MR, Marcucci, G, Chan, KK. Quantification of Valproic Acid and
its Metabolite 2-propyl-4-pentenoic Acid in
Human Plasma Using HPLC-MS/MS. J Chrom B, doi: 10.1016/j. chromb.2006.11.027, 850(1-2):206-212,
2007.
Colitz,
CMH, Latimer, FG, Cheng, H, Chan, KK, Reed, S, and Pennick, GJ. Pharmacokinetics of Voriconazole
Following Intravenous and Oral Administration and Body Fluid
Concentrations of Voriconazole Following Repeated Oral Administration
in Horses. Amer Journal of Vet
Res, 68(10): 1115-1121, 2007.
*Blum,
W, Klisovic, RB, Hackanson, B, Liu, Z, Liu, S, Devine, H,
Vukosavljevic, T, Huynh, L, Lozanski, G, Kefauver, C, Plass, C, Devine,
SM, Heerema, NA, Murgo, A, Chan,
KK, Grever, MR, Byrd, JC, and Marcucci, G. Phase 1 Study of Decitabine Alone or
in Combination with Valproic Acid in Acute Myeloid Leukemia. Journal of Clinical Oncology,
10.1200/JCO.2006.009.4169, 25(25):3884-3891, 2007.
*Liu,
Z, Xie, Z, Liu, S, Blum, W, Perrotti, D, Paschka, P, Klisovic, R, Byrd,
JC, Chan, KK, and Marcucci, G.
Characterization of In-Vitro and In-Vivo Hypomethylating Effect
of Decitabine in Acute Myeloid Leukemia by a Rapid, Specific and
Sensitive LC-MS/MS Method.
Nucleic Acid Research, 35(5) e31 doi:10.1093/nar/gkl1156, 2007.
*Liu,
Z, Fan-Havard, P, Xie, Z, Ren, C, and Chan, KK. A Liquid Chromatography/atmospheric
Pressure Ionization Tandem Mass Spectrometry Quantitation Method for
Nevirapine and its Two Oxidative Metabolites, 2-hydroxynevirapine and
Nevirapine 4-carboxylic Acid, and Pharmacokinetics in Baboons. Rapid Communications in Mass
Spectrometry, 21(16): 2734-2742, 2007.
Liu,
S, Klisovic, RB, Vukosavljevic, T, Yu, J, Paschka, P, Huynh, L, Pang,
J, Neviani, P, Liu, Z, Blum, W, Chan, KK, Perrotti, D and Marcucci,
G. Targeting AML1/ETO-HDAC
Repressor Complex: A Novel
Mechanism of Valproic Acid Mediated Gene Expression and Cellular
Differentiation in AML1/ETO-positive Acute Myeloid Leukemia Cells. JPET published on-line, Fast Forward, DOI:
10.1124/jpet.106.118406 , J Pharmacol Exp Thera, 321(3):953-960, 2007.
Fabbri,
M, Garzon, R, Cimmino, A, Liu, Z, Zanesi, N, Callegari, E, Liu, S,
Alder, H, Costinean, S, Fernandez-Cymering, C, Volinia, S, Guler, G,
Morrison, CD, Chan, KK, Marcucci, G, Calin, GA, Huebner, K, and Croce,
CM. MicroRNA-29 Family Reverts
Aberrant Methylation in Lung Cancer by Targeting DNA Methyltransferases
3A and 3B. PNAS, 104(40)
15805-15810, 2007.
Liu,
S, Liu, Z, Xie, Z, Pang, J, Yu, J, Lehmann, E, Huynh, L, Vukosavljevic,
T, Takeki, M, Klisovic, RB, Baiocchi, RA, Blum, W, Porcu, P, Garzon, R,
Byrd, JC, Perrotti, D, Caligiuri, MA,
Chan, KK, Wu, L-C, and Marcucci, G. Bortezomib Induces DNA
Hypomethylation and Silenced Gene Transcription by Interfering with
Sp1/NF-kB-dependent DNA Methylatransferase Activity in Acute Myeloid
Leukemia. Blood, prepublished
on-line DOI 10.1182/blood-2007-08-110171, 111(4):2364-2373, 2008.
Bekaii-Saab,
TS, Liu, J, Chan, KK, Balcerzak, SP, Ivy, PS, Grever, MR, and Kraut,
EH. A Phase I and
Pharmacokinetic Study of Weekly Oxaliplatin Followed by Paclitaxel in
Patients with Solid Tumors. Clin
Cancer Res, 14(11): 3434-3440, 2008.
Klisovic, RB, Blum, W,
Wei, X, Liu, S, Liu, Z, Xie, Z, Vukosavljevic, T, Kefauver, C, Huynh,
L, Pang, J, Zweibel, JA, Devine, S, Byrd, JC, Grever, MR, Chan, K, and
Marcucci, G. Phase 1 Study of
GTI-2040, an Antisense to Ribonucleotide Reductase, in Combination with
High-Dose Cytarabine in Patients with Acute Myeloid Leukemia. Clin Cancer Res, 14(12): 3889-3895. 2008.
Wei, X, Dai, G, Liu, Z, Cheng, H, Xie, X, Klisovic, R,
Marcucci, G, and Chan, KK. Enzyme
Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting
Ribonucleotide Reductase.
Drug Metabolism and Disposition, 36(11);2227-2233, 2008. doi: 10.1124/dmd.108.021295.
Yuan, J-M, Chan, KK, Coetzee,
GA, Castelao, JE, Watson, MA, Bell, DA, Wang, R, and Yu, MC. Genetic determinants in the
Metabolism of Bladder Carcinogens in Relation to Risk of Bladder
Cancer. Carcinogenesis,
29(7): 1386-1393, 2008.
Yang, X, Koh, CG, Liu, S, Pan,
X, Santhanam, R, Yu, B, Peng, Y, Pang, J, Golan, S, Talmon, Y, Jin, Y,
Muthusamy, N, Byrd, JC, Chan, KK, Lee, LJ, Marcucci, G, and Lee,
RJ. Transferrin
Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense
Oligodeoxyribonucleotide against Bcl-2.
Molecular Pharmaceutics, 6(1):221-230, 2008.
*Liu, Z, Zhang, Y, Hua YF,
Covey JM, Benbrook DM, and Chan KK.
Metabolism of a sulfur-containing heteroarotionoid antitumor
agent, SHetA2, using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass
Spectrometry, 22: 3371-3381, 2008.
Liu, Z, Xie, Z, Jones, W,
Pavlovicz, RE, Liu, S, Yu, J, Li, P-k, Liu, J, Fuchs, JR, Marcucci, G,
Li, C, and Chan, KK. Curcumin is
a Potent DNA Hypomethylation Agent.
Bioorganic & Medicinal Chemistry Letters, 19:706-709, 2009.
Garzon, R, Liu, S, Fabbri,
M, Liu, Z, Heaphy, CEA, Callegari, E, Schwind, S, Pang, J, Yu, J,
Muthusamy, N, Volinia, S, Blum, W, Rush, LJ, Perrotti, D, Andreeff, M,
Bloomfield, CD, Byrd, JC, Chan, K, Wu, L-C, Croce, CM, and Marcucci,
G. MicroRNA-29b induces global DNA hypomethylation and tumor
suppressor gene re-expression in acute myeloid leukemia by targeting
directly DNMT3A and 3B and indirectly DNMT1. Blood, 113: 6411 – 6418,
2009. doi:10.1182/blood-2008-07-170589
Liu, Z, Liu, S, Xie, Z,
Pavlovics, RE, Wu, J, Chen, P, Aimiuwu, J, Pang, J, Bhasin, D, Neviani,
P, Fuchs, JR, Plass, C, Li, P-K, Li, C, Huang, T-M, Wu, L-C, Rush, L,
Wang, H, Perrotti, D, Marcucci, G, and Chan, KK. DNA Methylation Modulation by a
Sesquiterpene Lactone Parthenolide.
Journal of Pharmaceutical and Experimental Therapeutics,
329(2):505-514, 2009. doi:10.1124/jpet.108.147934
*Chen, P, Liu, Z, Liu, S,
Xie, X, Aimiuwu, J, Pang, J, Klisovic, R,
Blum, W, Grever, MR, Marcucci, G, and Chan, KK. A LC-MS/MS method for the analysis of intracellular nucleoside
triphosphate levels. Pharm Res, 26(6): 1504-1515, 2009.
DOI:10.1007/s11095-009-9863-9
Ugalde, CM, Liu, Z, Ren, C, Chan, KK, Rodrigo, KA,
Ling, Y, Larsen, PE, Chacon, GE, Stoner, GD, Mumper, RJ, Fields, HW,
Mallery, SR. Bioavailability of anthocyanins delivered from a
bioadhesive black raspberry gel following topical intraoral application
in normal healthy volunteers.
Pharm Res 26(4): 977-86, 2009. DOI: 10.1007/s11095-008-9806-x
Farag, SS, Zhang, S,
Jansak, BS, Wang, X, Kraut, EH, Chan, KK. Phase II Trial of
Temsirolimus in Patients with Relapsed or Refractory Multiple Myeloma.
Leuk Res 33(11): 1475-80, 2009.
Jin, Y, Liu, S, Yu, B,
Golan, S, Koh, CG, Yang, J, Huynh, L, Yang, X, Pang, J, Muthusamy, N,
Chan, KK, Byrd, JC, Talmon, Y, Lee, LJ, Lee, RJ, Marcucci, G. Targeted
Delivery of Antisense Olideoxynucleotide by Transferrin Conjugated
pH-Sensitive Lipopolyplex Nanoparticles: A Novel Oligonucleotide-Based
Therapeutic Strategy in Acute Myeloid Leukemia. Mol Pharmaceu, 7(1):
196-206, 2010. DOI: 10.1021/mp900205r
Koh, CG, Zhang, X, Liu, S,
Golan S, Yu, B, Yang, X, Guan, J, Yan, J, Talmon, Y, Muthusamy, N,
Chan, KK, Byrd, JC, Lee, RJ, Marcucci, G, Lee, LJ. Delivery of Antisense Oligonucleotide
Lipopolyplex Nanoparticles Assembled by Microfluidic Hydrodynamic
Focusing. J Control Release. 141:62-69, 2010.
*Liu, Z, Wu, J, Xie, A,
Liu, S, Fan-Havard, P, Huang, T, Plass, C, Marcucci, G, Chan, KK. Quantification of Regional RNA Methylation
by Liquid Chromatography/Tandem Mass Spectrometry. Anal Biochem
391(2):106-13, 2009.
*Ren C, Fan-Havard P, Schlabritz-Loutsevitch
N, Ling Y, Chan KK, and Liu Z.
A Sensitive and Specific Liquid Chromatography/Tandem Mass Spectrometry
Method for Quantification of Nevirapine and Its Five Metabolites and
Their Pharmacokinetics in Baboons.
Biomedical Chromatography published online DOI 10.1002/mbc.1353,
2009.
*Ling Y, Ren C, Mallery
SR, Ugalde CM, Pei P, Saradhi UVR, Stoner GD, Chan KK, and Liu Z. A rapid and sensitive LC-MS/MS method
for quantification of four anthocynanins and its application in a
clinical pharmacology study of a bioadhesive black raspberry gel. J Chrom B, 877:4027-4034, 2009.
Jin Y, Liu S, Yu B, Golan S, Koh CG, Yang J, Huynh L, Yang X,
Pang J, Muthusamy N, Chan KK, Byrd JC, Talmon Y, Lee LJ, Lee RJ,
Marcucci G. Targeted Delivery of Antisense Oligodeoxynucleotide by
Transferrin Conjugated pH-Sensitive Lipopolyplex Nanoparticles: A Novel
Oligonucleotide-Based Therapeutic Strategy in Acute Myeloid Leukemia. Mol Pharmaceu, 7(1): 196-206, 2010. DOI: 10.1021/mp900205r
Koh CG, Zhang X, Liu S, Golan S, Yu B, Yang X, Guan J, Yan J,
Talmon Y, Muthusamy N, Chan KK,
Byrd JC, Lee RJ, Marcucci G, Lee LJ. (2010) Delivery of Antisense
Oligonucleotide Lipopolyplex Nanoparticles Assembled by Microfluidic
Hydrodynamic Focusing. J Control Release, 141:62-69, 2010.
*Blum KA, Liu Z, Lucas
DM, Chen P, Xie Z, Baiocchi R, Benson DM, Devine SM, Jones J, Andritsos
L, Flynn J, Plass C, Marcucci G, Chan KK, Grever MR, Byrd JC. Phase I trial of low
dose decitabine targeting DNA hypermethylation in patients with chronic
lymphocytic leukemia and non-Hodgkin lymphoma: dose-limiting
myelosuppression without evidence of DNA hypomethylation. Br J
Haematol, 2010 Apr 29. [Epub ahead of print] PMID: 20456354
Blum W, Garzon R, Klisovic RB, Schwind S, Walker A, Geyer S, Liu
S, Havelange V, Becker H, Schaaf L, Mickle J, Devine H, Kefauver C,
Devine SM, Chan KK, Heerema NA, Bloomfield CD, Grever MR, Byrd JC,
Villalona-Calero M, Croce CM, and Marcucci G. Clinical Response and miR-29b
Predictive Significance in Older AML Patients Treated with a 10-day
Schedule of Decitabine. PNAS,
107(16): 7473-7478, 2010. PMCID: PMC2867720
Liu S, Wu L-C, Pang J, Santhanam R, Schwind S, Wu Y-Z, Hickey
CJ, Yu J, Becker H, Maharry K, Radmacher MD, Li C, Whitman SP, Mishra
A, Stauffer N, Eiring AM, Briesewitz R, Baiocchi RA, Chan KK, Paschka P,
Caligiuri MA, Byrd JC, Croce CM, Bloomfield CD, Perrotti D, Garzon R,
and Marcucci G.
Sp1/NFkB/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid
Leukemia. Cancer Cell, 17:333-347,
2010. PMC2917066
*Kraut EH, Rhoades C, Zhang Y, Cheng H, Aimiuwu J, Chen P, Lang
J, Young DC, Agrawal A, Dancey J, Chan KK, and Grever MR. Phase 1 and Pharmacokinetic Study of
Erlotinib (OSI-774) in Combination with Docetaxel in Squamous Cell
Carcinoma of the Head and Neck (SSCHN).
Cancer, Chemotherapy and Pharmacol, Published Online 19 May 2010 DOI 10.1007/s00280-010-1332-y.
PMID: 20490801
*Chan KK, Liu Z, Xie Z, Chiu M, Wang H, Chen P, Dunkerson S,
Chiu M, Liu S, Triantafillou G, Garzon R, Croce CM, Byrd JC, Muthusamy
N, and Marcucci G. A Novel
Ultrasensitive Hybridization-Based ELISA Method for
2-Methoxyphosphorothioate MicroRNAs and Its In vitro and In vivo
Application. AAPS Journal 2010
Jul 13. [Epub ahead of print]. DOI:
10.1208/s12248-010-9214-0. PMID:
20625866.
*Saradhi UVR, Ling Y, Wang J, Chiu M, Schwartz EB, Fuchs JR,
Chan KK, and Liu Z. A liquid
Chromatography- Tandem Mass Spectrometric Method for Quantification of
Curcuminoids in Cell Medium and Mouse Plasma. J Chromb B 2010 Sep 17 [Epub ahead of
print] PMID: 20934924.
*Chen P, Aimiuwu J, Xie
Z, Wei X, Liu S, Klisovic R, Marcucci G, and Chan KK. Bio Chemical Modulation of
Aracytidine (Ara-C) effects by GTI-2040, a Ribonucleotide Reductase Inhibitor, in K562 Human
Leukemia Cells. AAPSJ
Mar;13(1):131-40, Epub 2010 Dec 30. PMID: 21191677.
Chan Y-M, Butler JP, Pinnell NE, Pralong FP, Crowley Jr. WF, Ren
C, Chan KK, and Seminara
SB. Kisspeptin resets the hypothalamic GnRH clock in men. Journal of Clinical Endicrinology and
Metabolism, in press 2011.
Tao L,
Xiang Y-B, Chan KK, Wang R, Gao Y-T, Yu MC, Yuan Y-M. Cytochrome
P4501A2 Phenotype and Bladder Cancer Risk: The Shanghai Bladder Cancer Study. International Journal of Cancer, in
press 2011.
*Hofmeister CC, Yang X, Pichiorri F, Chen P, Rozewski DM,
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