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Since 2003 (*MS related)
*Naasani,
I, Oh-hashi, F, Oh-hara, T, Feng, WY, Johnston,
J, Chan ,K, and Tsuruo,T.
Blocking Telomerase by Dietary
Polyphenols Is a Major Mechanism for Limiting the Growth of Human
Cancer Cells in vitro and in vivo. Cancer Res. 63: 824-830,
2003.
*Xiao,
JJ, Byrd, J, Marcucci, G,
Grever, M, and Chan, KK.* Identification of Thiols and Glutathione
Conjugates of Depsipeptide FK228 (FR901228), a Novel Histone Protein
Deacetylase Inhibitor, in the Blood. Rapid Comm Mass Spectrometry 17(8):757-766,
2003.
Klisovic,
MI, Maghraby, EA, Parthun, R, Guimond, M, Sklenar, AR, Whitman, SP,
Chan, KK, Murphy, T, Anon, J, Archer, KJ, Rush, LJ, Plass, C, Grever,
MR, Byrd, JC, and Marcucci, G.* Depsipeptide (FR 901228) Promotes
Histone Acetylation, Gene Transcription, Apoptosis, and its Activity is
Enhanced by DNA Methyltransferase Inhibitors in AML1/ETO-positive
leukemic cells. Leukemia 17:350-358, 2003.
Gao, H,
Yamasaki, EF, Chan, KK, Shen, LL, and Snapka, RM.* DNA Sequence
Specificity for Topoisomerase II Poisoning by the Quinoxaline
Anticancer Drugs XK469 and CQS. Mol Pharmacol 63(6): 1382-1388,
2003.
Castelao, JE, Yuan,
J-M, Gago-Dominguez, M, Skipper, PL, Tannenbaum, SR, Chan, KK, Watson,
MA, Bell, DA, Coetzee, GA, Ross, RK, and Yu, MC. Carotenoids/vitamin C
and Smoking-related Bladder Cancer. Int J Cancer 110: 417-423,
2004.
*Berg, SL,
Stone, J, Xiao, JJ, Chan, KK, Nuchtern, J, Dauser, R, McGuffey, L, and
Blaney SM. Plasma and Cerebrospinal Fluid Pharmacokinetics of
Depsipeptide (FR901228) in Nonhuman Primates. Cancer Pharmacol
Pharmacol 54(1):85-88, 2004.
*Hua,
Y, Fan-Havard,
P, and Chan, KK.* A
Subnanogram On-line Column-switch LC/MS/MS Quantification Method for
Nelfinavir and Methoxy-phenol Metabolite M1 in Rat Plasma. J Chromatog
B 809(1): 1-7, 2004.
Marcucci, G,
Stock, W, Dai, G, Klisovic, MI, Maharry, K, Shen, T, Liu, S, Larson,
RA, Caliguiri, MA, Bloomfield, CD, Chan, KK, Grever, MR, Byrd, JC. G
3139, a BCL-2 antisense oligonucleotide, in AML. Ann Hematol. 83:S93-4,
2004.
Roychowdhury, S,
Baiocchi, R, Vourganti, S, Bhatt, D, Blaser, BW, Freud, AG, Chou,
J,Chen, Chang-Shi, Xiao, JJ, Parthun, M, Chan, KK, Eisenbeis, CF,
Ferketich, AK, Grever, MR, Chen, Ching-Shih, and Caligiuri, MA.
Selective Efficacy of Depsipeptide in a Xenograft Model of Epstein-Barr
Virus-Positive Lymphoproliferative Disorder. J Natl Cancer Inst. 96(19):
4471457, 2004.
*Liu, Z, Floss,
HG, Cassady, JM, Xiao, J, and Chan, KK.
An API LC/MS/MS Quantitation Method for
Ansamitocin P-3 (AP3) and its Preclinical Pharmacokinetics. J Pharm
Biomed Anal 36(4): 815-821, 2004.
*Liu,
Z, Floss, HG, Cassady, JM, and Chan, KK. Metabolism Studies of the Anti-tumor Agent Maytansine and Its Analog
Ansamitocin P-3 Using Liquid Chromatography/Tandem Mass Spectrometry. J
Mass Spectrom. 40(3): 389-399, 2005.
John
M. Cassady, Kenneth K. Chan, Heinz G. Floss, and Eckhard Leistner.
Recent Developments in the maytansinoid antitumor agents. In Chem Pharm
Bull, 52(1)1-26, 2004. BOOK
CHAPTER
*Xiao, JJ,
Foraker, AB, Swaan, PW, Liu, S, Huang, Y, Dai, Z, Chen, J, Sadee, W,
Byrd,J, Marcucci, G, and Chan KK. Efflux of Depsipeptide FK228
(FR901228, NSC-630176) is Mediated by both P-glycoprotein and MRP1. J
Pharmacol Exp Thera. 313(1): 268-276, 2005.
*Byrd,
JC, Marcucci, G, Parthun, MR,
Xiao, JJ, Klisovic, RB, Moran, M, Lin, TS, Liu, S, Wickham, J, Davis,
ME, Lucas, DM, Fischer, B, Shank, R, Binkley, B, Wright, J, Chan, KK,
and Grever, MR. A phase 1 and
pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic
leukemia and acute myeloid leukemia. Blood 105(3): 959-957, 2005.
Otterson,
GA, Lavelle, J, Villalona-Calero, MA,
Shah, M, Wei, X, Chan, KK, Fischer, B, Grever, M. A Phase I Clinical
and Pharmacokinetic Study of Fenretinide Combined with Paclitaxel and
Cisplatin for Refractory Solid Tumors. Invest. New Drugs, 23(6):
555-562, 2005.
Xiao,
JJ, Huang, Y, Dai, Z, Liu, S, Chen, J, Covey, JM, Wright, JM, Byrd, J,
Marcucci, G, Sadée, W and Chan,
KK. Chemo-resistance to depsipeptide FK228 is mediated by reversible
MDR1 induction in human cancer cell lines. J Pharmacol Exp Thera. 314(1): 467-475, 2005.
Huang,
Y, Blower, PE, Yang, C, Barbacioru, C, Dai, Z, Zhang, Y, Xiao, JJ,
Chan, KK, and Sadée, W.
Correlating gene expression with chemical scaffolds of cytotoxic
agents: ellipticines as substrates and inhibitors of MDR1. The
Pharmacogenomics Journal 5:112-125, 2005.
Dai,
G, Chan, KK, Liu, S, Hoyt, D, Whitman, S, Klisovic, M, Shen, TS,
Caliguri, MA, Byrd, J, Grever, M, and Marcucci, G. Cellular uptake and
intracellular levels of the Bcl-2 antisense G3139 in cultured cells,
and treated patients with acute myeloid leukemia. Clin Cancer Res, 11(8):2998-3008,
2005.
Marcucci,
G, Stock, W, Dai, G, Klisovic, RB, Liu, S, Klisovic, MI, Blum, W,
Kefauver, C, Sher, DA, Green,
M, Moran, M, Maharry, K, Novick, S, Bloomfield, CD, Zwiebel, JA,
Larson, RA, Grever, MR, Chan, KK, and Byrd, JC. Phase I Study of Oblimersen Sodium, an
Antisense to Bcl-2, in Untreated Older Patients with Acute Myeloid
Leukemia: Pharmacokinetics, Pharmacodynamics and Clinical
Activity. J Clin Oncology, 23(15):
3404-3411, 2005.
*Dai,
G, Wei, X, Liu, Z, Liu, S, Marcucci, G, Chan, KK. Characterization and
quantification of Bcl-2 antisense G3139 and metabolites in plasma and
urine by ion-pair reversed phase HPLC coupled with electrospray
ion-trap mass spectrometry. J
Chromatogr B 825(2): 201-213, 2005. (Invited manuscript)
*Liu, Z, Chan,
KK, and Wang, JJ. Tandem mass spectrometric analysis of
cyclophosphamide, ifosfamide and their metabolites. Rapid Comm Mass
Spectrom, 19(18): 2581-2590, 2005.
Bekaii-Saab,
T, Mortazavi, A, Hicks, LG, Zalpuski, M, Pelley, R. J, Chan, KK,
and Kraut, EH. A phase II study
of chloroquinoxaline sulfonamide (CQS) in patients with metastatic
colorectal carcinoma (MCRC). Invest New Drugs 24(4):343-346,
2006.
Zhang,
Y, Hua, Y, Benbrook, D, Covey, JM, Dai, G, Liu, Z, and Chan, KK.
High Performance Liquid Chromatographic Analysis and Preclinical
Pharmacokinetics of the Heteroarotinoid Antitumor Agent, SHetA2.
Cancer Chemother Pharmacol. 58(5):561-569,
2006.
*Liu,
Z, Marcucci, G, Byrd, JC, Grever, M, Xiao, J, and Chan, KK. Characterization
of Decomposition Products and Preclinical and Low Dose Clinical
Pharmacokinetics of Decitabine (5-aza-2’-deoxycytidine) by a New
Liquid Chromatography Tandem Mass Spectrometry Quantification Method.
Rapid Comm Mass Spectrom, 20(7):1117-1126, 2006.
Wei,
X, Dai, G, Marcucci, G, Liu, Z, Hoyt, D, Blum, W, and Chan, KK. A
Specific Picomolar Hybridization-based ELISA Assay for the
Determination of Phosphorothioate Oligonucleotides in Plasma and
Cellular Matrices. Pharm Res, 23(6):1251-1264, 2006.
O’Connor, OA, Smith, EA, Toner, LE,
Teruya-Feldstein, J, Frankel, S, Rolfe, M, Wei, X, Liu, S, Marcucci, G,
Chan, KK, and Chanan-Khan, A. The Combination of the Proteasome
Inhibitor Bortezomib and the Bcl-2 Antisense Molecule Oblimersen
Sensitizes Human B-Cell Lymphomas to Cyclophosphamide. Clin Cancer Res,
12(9): 2902-2911, 2006.
Shah, MH, Binkley, P, Chan, KK, Xiao, J, Arbogast, D,
Collamore, M, Farra, Y, Young, D, Wright, J, and Grever, M.
Cardiotoxicity of Histone Deacetylase Inhibitor Depsipeptide in
Patients with Metastic Neuroendocrine Tumors. Clin Cancer Res, 12(13):
3997-4003, 2006.
Stram,
DO, Yuan, J-M, Chan, KK, Gao, Y-T, Ross, RK, Yu, MC. Beta-cryptoxanthin and Lung Cancer in
Shanghai, China -an Examination of
Potential Confounding with Cigarette Smoking Using Urinary Cotinine as
a Biomarker of True Tobacco Exposure.
Nutrition and Cancer, 57(2): 123-129, 2006.
*Perera,
M, Yin, D, Wu, D, Chan, KK, Miller, D, and Dalton, JT. In Vivo Metabolism and
Final Disposition of a Novel Nonsteroidal Androgen in Rats and
Dogs. Drug Metabolism and
Disposition, 34(10): 1713-1721, 2006.
Fang,
L, Zhang, G, Zhang, Li, C, Zheng, X, Zhu, L, Xiao, JJ, Szakacs, G,
Nadas, J, Chan, KK, Wang PG, and Sun, D. Discovery of a Daunorubicin Analogue
that Exhibits Potent Antitumor Activity and Overcomes P-gp-mediated
drug resistance. J Med Chem 49(3): 932-941, 2006.
Fang,
L, Battisti, RF, Cheng, H, Reigan, P, Xin, Y, Shen, J, Ross, D, Chan,
KK, Martin, EW, Wang, PG, and Sun, D.
Enzyme Specific Activation of Benzoquinone Ansamycin Prodrugs
Using HuCC49∆CH2-β-Galactosidase Conjugates. J Med Chem 49(21): 6290- 6297, 2006.
Fang,
L, Nicholas, HG, Holford, MB, Hinkle, G, Cao, X, Xiao, JJ, Bloomston,
MP, Gibbs, S, Al Saif, OH, Dalton, JT, Chan, KK, Schlom, J, Martin, E,
and Sun, D. Population Pharmacokinetics of Humanized Monoclonal
Antibody HuCC49∆CH2 and Murine Antibody CC49 in Colorectal Cancer
Patients. J Clin Pharmacol, 47(2): 227-237, 2007.
*Wei,
X, Dai, G, Liu, Z, Cheng, H, Xie, Z, Marcucci, G, Chan, KK. Metabolism of GTI-2040, a
Phosphorothioate Oligonucleotide Antisense, Using Ion-pair Reversed
Phase High Performance Liquid Chromatography (HPLC) Coupled with
Electrospray Ion-trap Mass Spectrometry. AAPSJ, 8(4) article 84, 2006. (Invited
manuscript)
*Cheng, H, Liu, Z, Blum, W,
Byrd, J, Klisovic, R, Grever, MR, Marcucci, G, Chan, KK. Quantification of Valproic Acid and
its Metabolite 2-propyl-4-pentenoic Acid in
Human Plasma Using HPLC-MS/MS. J Chrom B, doi: 10.1016/j. chromb.2006.11.027, 850(1-2):206-212,
2007.
Colitz,
CMH, Latimer, FG, Cheng, H, Chan, KK, Reed, S, and Pennick, GJ. Pharmacokinetics of Voriconazole
Following Intravenous and Oral Administration and Body Fluid
Concentrations of Voriconazole Following Repeated Oral Administration
in Horses. Amer Journal of Vet
Res, 68(10): 1115-1121, 2007.
*Blum,
W, Klisovic, RB, Hackanson, B, Liu, Z, Liu, S, Devine, H,
Vukosavljevic, T, Huynh, L, Lozanski, G, Kefauver, C, Plass, C, Devine,
SM, Heerema, NA, Murgo, A, Chan,
KK, Grever, MR, Byrd, JC, and Marcucci, G. Phase 1 Study of Decitabine Alone or
in Combination with Valproic Acid in Acute Myeloid Leukemia. Journal of Clinical Oncology,
10.1200/JCO.2006.009.4169, 25(25):3884-3891, 2007.
*Liu,
Z, Xie, Z, Liu, S, Blum, W, Perrotti, D, Paschka, P, Klisovic, R, Byrd,
JC, Chan, KK, and Marcucci, G.
Characterization of In-Vitro and In-Vivo Hypomethylating Effect
of Decitabine in Acute Myeloid Leukemia by a Rapid, Specific and
Sensitive LC-MS/MS Method.
Nucleic Acid Research, 35(5) e31 doi:10.1093/nar/gkl1156, 2007.
*Liu,
Z, Fan-Havard, P, Xie, Z, Ren, C, and Chan, KK. A Liquid Chromatography/atmospheric
Pressure Ionization Tandem Mass Spectrometry Quantitation Method for
Nevirapine and its Two Oxidative Metabolites, 2-hydroxynevirapine and
Nevirapine 4-carboxylic Acid, and Pharmacokinetics in Baboons. Rapid Communications in Mass
Spectrometry, 21(16): 2734-2742, 2007.
Liu,
S, Klisovic, RB, Vukosavljevic, T, Yu, J, Paschka, P, Huynh, L, Pang,
J, Neviani, P, Liu, Z, Blum, W, Chan, KK, Perrotti, D and Marcucci,
G. Targeting AML1/ETO-HDAC
Repressor Complex: A Novel
Mechanism of Valproic Acid Mediated Gene Expression and Cellular
Differentiation in AML1/ETO-positive Acute Myeloid Leukemia Cells. JPET published on-line, Fast Forward, DOI:
10.1124/jpet.106.118406 , J Pharmacol Exp Thera, 321(3):953-960, 2007.
Fabbri,
M, Garzon, R, Cimmino, A, Liu, Z, Zanesi, N, Callegari, E, Liu, S,
Alder, H, Costinean, S, Fernandez-Cymering, C, Volinia, S, Guler, G,
Morrison, CD, Chan, KK, Marcucci, G, Calin, GA, Huebner, K, and Croce,
CM. MicroRNA-29 Family Reverts
Aberrant Methylation in Lung Cancer by Targeting DNA Methyltransferases
3A and 3B. PNAS, 104(40)
15805-15810, 2007.
Liu,
S, Liu, Z, Xie, Z, Pang, J, Yu, J, Lehmann, E, Huynh, L, Vukosavljevic,
T, Takeki, M, Klisovic, RB, Baiocchi, RA, Blum, W, Porcu, P, Garzon, R,
Byrd, JC, Perrotti, D, Caligiuri, MA,
Chan, KK, Wu, L-C, and Marcucci, G. Bortezomib Induces DNA
Hypomethylation and Silenced Gene Transcription by Interfering with
Sp1/NF-kB-dependent DNA Methylatransferase Activity in Acute Myeloid
Leukemia. Blood, prepublished
on-line DOI 10.1182/blood-2007-08-110171, 111(4):2364-2373, 2008.
Bekaii-Saab,
TS, Liu, J, Chan, KK, Balcerzak, SP, Ivy, PS, Grever, MR, and Kraut,
EH. A Phase I and
Pharmacokinetic Study of Weekly Oxaliplatin Followed by Paclitaxel in
Patients with Solid Tumors. Clin
Cancer Res, 14(11): 3434-3440, 2008.
Klisovic, RB, Blum, W,
Wei, X, Liu, S, Liu, Z, Xie, Z, Vukosavljevic, T, Kefauver, C, Huynh,
L, Pang, J, Zweibel, JA, Devine, S, Byrd, JC, Grever, MR, Chan, K, and
Marcucci, G. Phase 1 Study of
GTI-2040, an Antisense to Ribonucleotide Reductase, in Combination with
High-Dose Cytarabine in Patients with Acute Myeloid Leukemia. Clin Cancer Res, 14(12): 3889-3895. 2008.
Wei, X, Dai, G, Liu, Z, Cheng, H, Xie, X, Klisovic, R,
Marcucci, G, and Chan, KK. Enzyme
Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting
Ribonucleotide Reductase.
Drug Metabolism and Disposition, 36(11);2227-2233, 2008. doi: 10.1124/dmd.108.021295.
Fast-forward Published on-line, July 24, 2008.
Yuan, J-M, Chan, KK,
Coetzee, GA, Castelao, JE, Watson, MA, Bell, DA, Wang, R, and Yu,
MC. Genetic determinants in the
Metabolism of Bladder Carcinogens in Relation to Risk of Bladder
Cancer. Carcinogenesis,
29(7): 1386-1393, 2008.
Yang, X, Koh, CG, Liu, S,
Pan, X, Santhanam, R, Yu, B, Peng, Y, Pang, J, Golan, S, Talmon, Y,
Jin, Y, Muthusamy, N, Byrd, JC, Chan, KK, Lee, LJ, Marcucci, G, and
Lee, RJ. Transferrin
Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense
Oligodeoxyribonucleotide against Bcl-2.
Molecular Pharmaceutics, 6(1):221-230, 2008.
*Liu, Z, Zhang, Y, Hua YF,
Covey JM, Benbrook DM, and Chan KK.
Metabolism of a sulfur-containing heteroarotionoid antitumor
agent, SHetA2, using liquid chromatography/tandem mass
spectrometry. Rapid
Communications in Mass Spectrometry, 22: 3371-3381, 2008.
Liu, Z, Xie, Z, Jones, W,
Pavlovicz, RE, Liu, S, Yu, J, Li, P-k, Liu, J, Fuchs, JR, Marcucci, G,
Li, C, and Chan, KK. Curcumin is
a Potent DNA Hypomethylation Agent.
Bioorganic & Medicinal Chemistry Letters, 19:706-709, 2009.
Garzon, R, Liu, S, Fabbri,
M, Liu, Z, Heaphy, CEA, Callegari, E, Schwind, S, Pang, J, Yu, J,
Muthusamy, N, Volinia, S, Blum, W, Rush, LJ, Perrotti, D, Andreeff, M,
Bloomfield, CD, Byrd, JC, Chan, K, Wu, L-C, Croce, CM, and Marcucci,
G. MicroRNA-29b induces global DNA hypomethylation and tumor
suppressor gene re-expression in acute myeloid leukemia by targeting
directly DNMT3A and 3B and indirectly DNMT1. Blood, doi:10.1182/blood-2008-07-170589, pre-published online
February 11, 2009.
Liu, Z, Liu, S, Xie, Z,
Pavlovics, RE, Wu, J, Chen, P, Aimiuwu, J, Pang, J, Bhasin, D, Neviani,
P, Fuchs, JR, Plass, C, Li, P-K, Li, C, Huang, T-M, Wu, L-C, Rush, L,
Wang, H, Perrotti, D, Marcucci, G, and Chan, KK. DNA Methylation Modulation by a
Sesquiterpene Lactone Parthenolide.
Journal of Pharmaceutical and Experimental Therapeutics,
doi:10.1124/jpet.108.147934.
Fast-forward Published on-line, February 6, 2009.
*Chen, P, Liu, Z, Liu, S, Xie, X,
Aimiuwu, J, Pang, J, Klisovic,
R, Blum, W, Grever, MR, Marcucci, G, and Chan, KK. A LC-MS/MS
method for the analysis of intracellular nucleoside triphosphate
levels. Pharm Res, in press,
February 2009.
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